The focus of the lab is to understand how the vertebrate limb is patterned. We primarily use classical grafting approaches coupled with modern molecular and genetic approaches in avian embryos (chick and quail). Click images for relevant papers.
Sonic hedgehog signalling
A longstanding interest in the lab is how Sonic hedgehog (Shh) signalling patterns the antero-posterior (thumb to little finger) axis of the developing limb bud
A longstanding interest in the lab is how Sonic hedgehog (Shh) signalling patterns the antero-posterior (thumb to little finger) axis of the developing limb bud
Shh and growth
with Cheryll Tickle |
Shh and digit identity
with Cheryll Tickle |
Shh and digit number
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Modelling Shh
with Thomas Woolley |
Timing limb development
Recently we have focussed on the temporal control of growth and patterning in limb development and how this controls limb size
Recently we have focussed on the temporal control of growth and patterning in limb development and how this controls limb size
Timing limb patterning
(with Marian Ros) |
Timing Shh
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Defective timing in congenital disease
(with James Poulter and Eamonn Sheridan) |
Timing limb growth
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Limb evolution
We are always interested in evo-devo projects in limb development
We are always interested in evo-devo projects in limb development
Evolution and patterning of feathers
Hypothalamic development
With Marysia Placzek we are extrapolating limb patterning models onto hypothalamic development
With Marysia Placzek we are extrapolating limb patterning models onto hypothalamic development
Shh and growth